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Devyser CFTR Core

Allele-specific genotyping of a panel of normal and mutated alleles in the CFTR gene common in the European population.

36

Detects the 36 most common mutations found in populations of European origin

Allele-specific detection of wild-type and variants

CFTR

Detects polythymidine variants (5T/7T/9T) within intron 9 (IVS8) of the CFTR

The next generation is here!

A complete CFTR kit for first level mutation screening

The Devyser CFTR Core kit is designed to genotype the normal and mutant alleles at 33 loci of the CFTR gene using purified human genomic DNA. Genotype coverage includes a panel of 36 mutations common in multiethnic European populations.The assay also detects poly-thymidine variants (5T/7T/9T) within intron 9(IVS8) of the CFTR gene. In case of a 5T allele, the TG repeat number upstream of the poly-T region can also be determined. The Devyser CFTR Core kit is based on multiplex allele-specific PCR amplification for detection of normal, non-mutated and mutated alleles in the CFTR gene. Allele-specific PCR amplification generates fluorescently labelled fragments that are analyzed by capillary electrophoresis on a Genetic Analyzer instrument. Amplified fragments are identified based on size and fluorescent labels.

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Instructions for use

Enter access code found in the lower right corner of the label on the kit box.

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Certificates

Download a specific Batch Release Certificate (BRC) below.

Guidelines and handbooks (4)

CFTR - Best Practice Guidelines (EU) (English)

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Accessory Pack Devyser CFTR Core version 2018-08-20 (English)

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Data Analysis Using GeneMapper 2018-12-10 (English)

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Handbook Devyser CFTR Core RUO EN v2020-10-13 (English)

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Product information (2)

Flyer: Devyser CFTR Core (English) (English)

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Flyer: Devyser CFTR Core (Italian) (Italian)

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Software settings (9)

GeneMapper Settings Devyser CFTR Core (Sep_POP4)_GM4-5_2018-01-10 (English)

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GeneMapper Settings Devyser CFTR Core (Sep_POP7)_HGVS_GM4-5_2018-01-10 (English)

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GeneMapper Settings Devyser CFTR Core (Ov_POP4)_GM4-5_2018-08-08 (English)

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GeneMapper Settings Devyser CFTR Core (Sep_POP7)_GM4-5_2018-01-10 (English)

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GeneMapper Settings Devyser CFTR Core (Ov_POP7)_GM4-5_2018-01-10 (English)

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Fragment Analysis Using ABI PRISM 310_2020-06-15 (English)

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Fragment Analysis Using ABI 3730 & 3730xL 2020-06-15 (English)

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Fragment Analysis Using ABI 3130 & 3130xL 2020-06-15 (English)

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Fragment Analysis Using ABI 3500 & 3500xL 2020-06-15, c2021-01-19 (English)

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Safety data sheets (5)

Devyser SDS 2 RUO EN (English)

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Devyser SDS 1 CE-IVD EN (English)

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Devyser SDS 2 RUO DE (German)

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Devyser SDS 1 CE-IVD IT (Italian)

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Devyser SDS 2 RUO IT (Italian)

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Data tables (2)

Table: Reported insertions and deletions Devyser CFTR Core v2018-02-08 (English)

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Table: Reported primer site polymorphisms and mutations Devyser CFTR Core v2018-03-26 (English)

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Enter access code found in the lower right corner of the label on the kit box.

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Product details

CE-IVD

Devyser CFTR Core

Detection of the following CFTR mutations: 711+1G>T, 3120+1G>A, 621+1G>T, 1717-1G>A, CFTRdele2,3(21kb), 3849+10kbC>T, 2789+5G>A, 1898+1G>A, G542X, G85E, Y1092X(C>A), G551D, R553X, 3659delC, N1303K, R560T, R117H, R1162X, L1077P, R117C, R1066C, L1065P, W1282X, R347H, R347P, I507del, T338I, F508del, I336K, 1677delTA, R334W, 3272-26A>G, 1078delT, 2183AA>G, 2184insA, 2143delT and corresponding wildtype alleles. IVS8: 5T (including identification of TG9-13), 7T, 9T. Calibrated with DEV-5

8-A031

Pack size: 48

RUO

Devyser CFTR Core

Detection of the following CFTR mutations: 711+1G>T, 3120+1G>A, 621+1G>T, 1717-1G>A, CFTRdele2,3(21kb), 3849+10kbC>T, 2789+5G>A, 1898+1G>A, G542X, G85E, Y1092X(C>A), G551D, R553X, 3659delC, N1303K, R560T, R117H, R1162X, L1077P, R117C, R1066C, L1065P, W1282X, R347H, R347P, I507del, T338I, F508del, I336K, 1677delTA, R334W, 3272-26A>G, 1078delT, 2183AA>G, 2184insA, 2143delT and corresponding wildtype alleles. IVS8: 5T (including identification of TG9-13), 7T, 9T. Calibrated with DEV-5. Calibrated with DEV-5

8-A031-RUO

Pack size: 48

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