Devyser FH NGS
Reduce hands-on time from days to minutes with Devyser’s easy-to-use NGS library prep kit for complete characterization of genes involved in familial hypercholesterolemia.
FH
Comprehensive gene panel for Familial hypercholesterolemia (FH)
12
Identify 12 SNPs in polygenic FH & the 6 SNPs to predict statin response
Single-tube workflow for fast results
Product information
Designed for routine laboratory use
The Devyser FH kit is easy to implement and a highly cost-effective solution for NGS library preparation. With ready-to-use reagents and a user-friendly workflow, it suits both manual and automated processes. Familial Hypercholesterolemia, also known as Autosomal Dominant Hypercholesterolemia (ADH), can be caused by mutations in the LDLR, APOB, PCSK9, APOE, STAP1 and LDLRAP1 genes, all of which can be detected with Devyser’s FH kit. Raised LDL-cholesterol concentrations can also have a polygenic cause that might explain the variable penetrance of the disease. Devyser’s FH kit enables the analysis of 12 polygenic SNPs influencing the LDL-cholesterol level.
Predict the effects of statin therapy
Statin drugs are highly effective in lowering blood concentrations of LDL-cholesterol, with concomitant reduction in risk of major cardiovascular events. Although statins are generally regarded as safe and well-tolerated, there is an interindividual difference in the response to statin treatment and some users may develop muscle symptoms, myopathy. Devyser FH enables the detection of several SNPs associated with treatment effect and adverse reactions to statin therapy.
Downloads
Instructions for use
Enter access code found in the lower right corner of the label on the kit box.
Certificates
Download a specific Batch Release Certificate (BRC) below.
Guidelines and handbooks (2)
Product information (2)
Software settings (9)
Safety data sheets (1)
Data tables (0)
Enter access code found in the lower right corner of the label on the kit box.
Download a specific Batch Release Certificate (BRC) below.
Product details
RUO
Devyser FH NGS
Complete sequencing of the following genes: LDLR, APOB, PCSK9, APOE, STAP1, LDLRAP1 Sequence determination of the following polygenic SNPs related to FH and/or statin treatment response: rs629301, rs1564348, rs1800562, rs2479409, rs3757354, rs4299376, rs6511720, rs8017377, rs11220462, rs1367117, rs429358, rs7412, rs646776, rs4149056, rs3798220, rs10455872
8-A109-24-RUO
8-A109-48-RUO
Pack size: 24
Pack size: 48
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Disclaimer: Devyser FH is for research use only (RUO) not for use in diagnostic procedures.