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Devyser FH NGS

Reduce hands-on time from days to minutes with Devyser’s easy-to-use NGS library prep kit for complete characterization of genes involved in familial hypercholesterolemia.


Comprehensive gene panel for Familial hypercholesterolemia (FH)


Identify 12 SNPs in polygenic FH & the 6 SNPs to predict statin response

Test tube icon

Single-tube workflow for fast results

Product information

Designed for routine laboratory use

The Devyser FH kit is easy to implement and a highly cost-effective solution for NGS library preparation. With ready-to-use reagents and a user-friendly workflow, it suits both manual and automated processes. Familial Hypercholesterolemia, also known as Autosomal Dominant Hypercholesterolemia (ADH), can be caused by mutations in the LDLR, APOB, PCSK9, APOE, STAP1 and LDLRAP1 genes, all of which can be detected with Devyser’s FH kit. Raised LDL-cholesterol concentrations can also have a polygenic cause that might explain the variable penetrance of the disease. Devyser’s FH kit enables the analysis of 12 polygenic SNPs influencing the LDL-cholesterol level.

Predict the effects of statin therapy

Statin drugs are highly effective in lowering blood concentrations of LDL-cholesterol, with concomitant reduction in risk of major cardiovascular events. Although statins are generally regarded as safe and well-tolerated, there is an interindividual difference in the response to statin treatment and some users may develop muscle symptoms, myopathy. Devyser FH enables the detection of several SNPs associated with treatment effect and adverse reactions to statin therapy.


Instructions for use

Enter access code found in the lower right corner of the label on the kit box.

product card


Download a specific Batch Release Certificate (BRC) below.

Guidelines and handbooks (2)

Handbook Devyser FH v2 RUO 2020-01-09 (English)


Addendum to handbook Devyser VeritiPro NGS products 7-B902 v2023-03-31 (English)

99 kb pdf

Product information (2)

Flyer - Devyser FH v2 (English)


Flyer Italian FHv2 (Italian)


Software settings (9)

MiSeq IEM Files (English)


Illumina double index (English)


SeqNext Guide Devyser FH v2 EN 2019-11-27 (English)


Devyser-FH_Hg19_2019-05-07 (English)


Devyser-FH_DirectDetections_2019-05-07 (English)

Devyser-FH_Hg38_2019-05-07 (English)


Devyser FHv2 SN4.3 Hg38 2019-10-07 (English)


Devyser FHv2 SN4.3 Hg19 2019-10-07 (English)


Devyser FH LRM files v2023-11-01 (English)

72 kb zip

Safety data sheets (1)

SDS Devyser NGS products 7-A428 v2024-01-10 (English)

486 kb pdf

Data tables (0)

Enter access code found in the lower right corner of the label on the kit box.

product card

Product details


Devyser FH NGS

Complete sequencing of the following genes: LDLR, APOB, PCSK9, APOE, STAP1, LDLRAP1 Sequence determination of the following polygenic SNPs related to FH and/or statin treatment response: rs629301, rs1564348, rs1800562, rs2479409, rs3757354, rs4299376, rs6511720, rs8017377, rs11220462, rs1367117, rs429358, rs7412, rs646776, rs4149056, rs3798220, rs10455872



Pack size: 24

Pack size: 48

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