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Devyser HFE

Multiplex PCR reagent kit for the simultaneous detection of the three most common mutations, and corresponding wildtypes, in the HFE gene.

HFE

Multiplex detection of the three most important HFE mutations and the corresponding wild types

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Single-tube PCR

Product information

Hereditary hemochromatosis

Hereditary hemochromatosis (HH) is a common autosomal recessive disorder of iron metabolism resulting in progressive accumulation of iron. Excess iron is deposited in a variety of organs leading to irreversible tissue damage,particularly in the liver and pancreas. The symptoms include liver cirrhosis, cardiomyopathy, hepatomas, diabetes, arthritis and hypogonadotropic hypogonadism. Classic, or type 1 HH, is caused by mutation in the HFE gene on chromosome 6p21.3. More than 80% of HH patients carry homozygous C282Y mutation. In addition, an increased risk of developing HH has also been shown in individuals where the compound heterozygosity C282Y/H63D is present. The findings are similar for individuals that are compound heterozygous for S65C and C282Y.

Diagnosis and treatment

Confirmatory diagnostic testing to diagnose or rule out HH should be carried out for symptomatic individuals with biochemical evidence of iron overload. Early diagnosis is crucial since severe effects of the disease may occur if the condition is left untreated. Removal of excess iron by therapeutic phlebotomy decreases morbidity and mortality if instituted early in the course of the disease.

Indications for Devyser HFE

Patients with HH Patients with early HH symptoms Identification of carriers in affected families Differential diagnosis in chronic viral hepatitis or alcohol-induced liver damage

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Instructions for use

Enter access code found in the lower right corner of the label on the kit box.

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Certificates

Download a specific Batch Release Certificate (BRC) below.

Guidelines and handbooks (6)

Data Analysis Using GeneMapper 2018-12-10 (English)

pdf

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Devyser HFE Handbook 7-A125 AA v2 (English) (English)

350 kb pdf

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Addendum to handbook Devyser SeqStudio allele-specific products 7-B908 v2023-03-30 (English)

489 kb pdf

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Addendum to handbook Devyser VeritiPro allele-specific products 7-B906 v2023-03-31 (English)

82 kb pdf

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Addendum to Handbook 560 SIZER ORANGE Correction storage requirements 7-B917 v2024-09-13 (English)

106 kb pdf

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Addendum to Handbook Dev-5 Dye Set MultiCap Correction storage requirements 7-B916 v2024-09-13 (English)

121 kb pdf

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Product information (2)

IT Flyer - Devyser HFE v2 (Italian)

pdf

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Flyer - Devyser HFE v2 (English)

pdf

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Software settings (7)

GeneMapper Settings Devyser HFE v2_GM4-5_2018-01-10 (English)

zip

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Fragment Analysis Using ABI PRISM 310_2020-06-15 (English)

pdf

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Fragment Analysis Using ABI 3730 & 3730xL 2020-06-15 (English)

pdf

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Fragment Analysis Using ABI 3130 & 3130xL 2020-06-15 (English)

pdf

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Fragment Analysis Using ABI 3500 & 3500xL 2020-06-15, c2021-01-19 (English)

pdf

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Fragment analysis using SeqStudio v2023-02-13 (English)

pdf

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Devyser Seqstudio Settings v.2022-12-29 (English)

4 kb

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Safety data sheets (1)

SDS Devyser FA products 7-A429 (English)

569 kb pdf

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Data tables (0)

Enter access code found in the lower right corner of the label on the kit box.

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Product details

CE-IVD

Devyser HFE

Detection of C282Y, H63D, S65C and their corresponding wild type alleles

8-A030.2

Pack size: 48

RUO

Devyser HFE

Detection of C282Y, H63D, S65C and their corresponding wild type alleles

8-A030.2-RUO

Pack size: 48

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Disclaimer: Products mentioned here are CE-IVD marked but not FDA-cleared. Availability in each country depends on local regulatory marketing authorization status. Please consult your local sales representative for details.