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Devyser HFE

Multiplex PCR reagent kit for the simultaneous detection of the three most common mutations, and corresponding wildtypes, in the HFE gene.

HFE

Multiplex detection of the three most important HFE mutations and the corresponding wild types

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Single-tube PCR

Product information

Hereditary hemochromatosis

Hereditary hemochromatosis (HH) is a common autosomal recessive disorder of iron metabolism resulting in progressive accumulation of iron. Excess iron is deposited in a variety of organs leading to irreversible tissue damage,particularly in the liver and pancreas. The symptoms include liver cirrhosis, cardiomyopathy, hepatomas, diabetes, arthritis and hypogonadotropic hypogonadism. Classic, or type 1 HH, is caused by mutation in the HFE gene on chromosome 6p21.3. More than 80% of HH patients carry homozygous C282Y mutation. In addition, an increased risk of developing HH has also been shown in individuals where the compound heterozygosity C282Y/H63D is present. The findings are similar for individuals that are compound heterozygous for S65C and C282Y.

Diagnosis and treatment

Confirmatory diagnostic testing to diagnose or rule out HH should be carried out for symptomatic individuals with biochemical evidence of iron overload. Early diagnosis is crucial since severe effects of the disease may occur if the condition is left untreated. Removal of excess iron by therapeutic phlebotomy decreases morbidity and mortality if instituted early in the course of the disease.

Indications for Devyser HFE

Patients with HH Patients with early HH symptoms Identification of carriers in affected families Differential diagnosis in chronic viral hepatitis or alcohol-induced liver damage

Downloads

Instructions for use

Enter access code found in the lower right corner of the label on the kit box.

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Certificates

Download a specific Batch Release Certificate (BRC) below.

Guidelines and handbooks (1)

Data Analysis Using GeneMapper 2018-12-10 (English)

pdf

Product information (2)

IT Flyer - Devyser HFE v2 (Italian)

pdf

Flyer - Devyser HFE v2 (English)

pdf

Software settings (5)

GeneMapper Settings Devyser HFE v2_GM4-5_2018-01-10 (English)

zip

Fragment Analysis Using ABI PRISM 310_2020-06-15 (English)

pdf

Fragment Analysis Using ABI 3730 & 3730xL 2020-06-15 (English)

pdf

Fragment Analysis Using ABI 3130 & 3130xL 2020-06-15 (English)

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Fragment Analysis Using ABI 3500 & 3500xL 2020-06-15, c2021-01-19 (English)

pdf

Safety data sheets (5)

Devyser SDS 2 RUO EN (English)

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Devyser SDS 1 CE-IVD EN (English)

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Devyser SDS 2 RUO DE (German)

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Devyser SDS 1 CE-IVD IT (Italian)

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Devyser SDS 2 RUO IT (Italian)

pdf

Data tables (0)

Enter access code found in the lower right corner of the label on the kit box.

product card

Product details

CE-IVD

Devyser HFE

Detection of C282Y, H63D, S65C and their corresponding wild type alleles

8-A030.2

Pack size: 48

RUO

Devyser HFE

Detection of C282Y, H63D, S65C and their corresponding wild type alleles

8-A030.2-RUO

Pack size: 48

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