“As a cost-effective rapid strategy that can detect mosaicism, QF-PCR will continue to have an essential role in prenatal diagnostic strategy.”
Dr. Kathy Mann, PhD, Principal Clinical Scientist within the Cytogenetics Department, GSTS Pathology, Guy's Hospital, London, United Kingdom.
When why means Y
Y-chromosome microdeletions is the most common genetic cause of male infertility. Screening for these microdeletions in men who are azoospermic (completely lack sperm in the ejaculate) or severely oligozoospermic (have less than 5 million spermatozoa in the ejaculate) is now standard practice in many infertility centers.
Three ASF regions
Y-chromosome screening typically seeks to identify microdeletions in three azoospermia factor (AZF) regions in the long arm of the Y chromosome. These are known as AZFa, AZFb and AZFc and are important to male fertility because they house genes required for sperm production.
Know. Decide. Act
Determining the status of microdeletions in AZFa, AZFb and AZFc using PCR analysis is an important screening tool that helps infertile or near-infertile men to take informed decisions regarding assisted reproductive techniques.
PCR analysis of AZF microdeletions can also provide valuable input into genetic counselling for the male patient or couple.
Devyser Resolution XY
Rapid quantitative analysis for stand alone, resolution or reflex testing of chromosomes ...
All markers detected
By using a single-tube testing solution, we simplify the lab workflow, reduce hands-on time, and minimize any risk of sample mix-up and contamination during basic and extended AZF analysis
Our tests detect all markers required for basic and extended AZF deletion screening. Capillary electrophoresis automatically identifies sequence-tagged site (STS) markers.
The single-tube PCR workflow is highly efficient and saves time, with rapid quantitative analysis for standalone, resolution or reflex testing of Y chromosomes.
Analysis made easy
Fast and effective test data analysis is crucial to achieving accurate outcomes and efficient workflows.
Dedicated software in our products makes analyzing test results quick, easy and trouble-free. For lab personnel, this means a streamlined end-to-end process with unmatched reliability and transparency.Find out more
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