Devyser Thalassemia v2: The all-in-one NGS solution - Webinar recap

The landscape of genetic testing for thalassemia is evolving, and Devyser is at the forefront of this transformation. Our recent webinar introduced Devyser Thalassemia v2, our next-generation sequencing (NGS) solution designed to simplify thalassemia testing with enhanced coverage and a streamlined workflow.

If you missed the live event, you can access the on-demand recording. 

Key takeaways from the webinar 

Overcoming challenges in thalassemia testing 

Traditional thalassemia genetic testing is complex, requiring multiple molecular techniques and lengthy turnaround times. This patchwork approach can lead to undetected variants, sample mix-ups, and high costs. Devyser Thalassemia v2 addresses these issues by offering a single, efficient NGS assay that detects all alpha and beta thalassemia variants, including single nucleotide variants (SNVs) and copy number variations (CNVs), with minimal hands-on time. 

Enhanced coverage and precision 

The latest version of our assay expands the target region across the globin gene clusters, incorporating sequencing of key thalassemia-related genes (HBA1, HBA2, HBB, HBD, HBG1, and HBG2). In addition, new beta thalassemia modifiers (such as KLF1) have been included. 

Comprehensive CNV detection 

A standout feature of Devyser Thalassemia v2 is the inclusion of an accurate direct detection for challenging deletions in HBA homologous regions:  

• Direct detection method – GAP-PCR-based detection method allows the accurate analysis of 19 deletions. The addition of a long-range PCR allows the inclusion of a direct detection of α3.7 and α4.2 deletions. 

User-friendly workflow and software 

Devyser Thalassemia v2 maintains an intuitive, same-day workflow, requiring only 10 nanograms of DNA input. The dedicated Amplicon suite software simplifies variant analysis, eliminating the need for bioinformatics expertise. With built-in database links to ClinVar and IthaNet, users can interpret results with ease and efficiency. 

Why choose Devyser Thalassemia v2? 

• Comprehensive detection: Covers all thalassemia variant types, including beta modifiers. 

• Improved accuracy: Robust CNV calling in homologous HBA genes. 

• Fast and efficient: Minimal hands-on time allows same-day library prep. 

• Scalable solution: Batch export options to accommodate growing lab needs. 

Watch the webinar on-demand 

If you’re looking for a faster, more comprehensive, and cost-efficient solution for thalassemia genetic testing, Devyser Thalassemia v2 is the answer. To learn more, watch the webinar on-demand now. 

Access the webinar

Disclaimer: Devyser Thalassemia v2 is for research use only (RUO). Not for use in diagnostic procedures.