oncology

CRISPR Helps BRCA1 Researchers Determine Functional And Non-Functional Mutations

BRCA1 variants may generally be divided into three categories: benign variants, which cause no clinical concern; deleterious variants, which are associated with high risk of cancer and variants of uncertain significance (VUS). Although millions of women worldwide have been sequenced for BRCA1 and 2, VUS continue to pose an important clinical problem for geneticists when …

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Recent Research in Predicting Onset of AML – Oncology

Two new studies attempting to define the genetic landscape of individuals who later develop Acute Myeloid Leukemia (AML) were recently published in Nature and Nature Medicine Nature Medicine published a report (P Desai et al) regarding 212 women from the Women’s Health Initiative who were healthy at study baseline, but eventually developed AML during follow-up …

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