BRCA1

Novel Somatic BRCA2 Variant Identified using the Devyser BRCA NGS kit.

In a case study published in Human Genome Variation (Costella et al. 2018), a novel somatic pathogenic variant of the BRCA2 gene was identified using the Devyser BRCA kit for next-generation sequencing (NGS). The paper concludes that the Devyser BRCA kit is able to detect variants at low admixture levels in tissue, simplifying what has …

Novel Somatic BRCA2 Variant Identified using the Devyser BRCA NGS kit. Read More »

Easily identify BRCA1 and BRCA2 genetic mutations

With cancer identified as the leading cause of death in high-income countries, early identification and treatment of cancer, and potential cancer-causing genetic variants, is essential. As the second most common cancer worldwide, and the most frequently diagnosed cancer among women, breast cancer nonetheless has a high survival rate if diagnosed and treated. Read more about …

Easily identify BRCA1 and BRCA2 genetic mutations Read More »

Cancer overtaking heart disease as leading cause of death

Cancer is overtaking heart disease as the leading cause of death, according to a study published recently in The Lancet medical journal. While heart disease remains the overall leading cause globally, the study of nearly 156k participants, across 21 countries over 11 years, has identified a trend that as living conditions improve, cancer begins to …

Cancer overtaking heart disease as leading cause of death Read More »

CRISPR Helps BRCA1 Researchers Determine Functional And Non-Functional Mutations

BRCA1 variants may generally be divided into three categories: benign variants, which cause no clinical concern; deleterious variants, which are associated with high risk of cancer and variants of uncertain significance (VUS). Although millions of women worldwide have been sequenced for BRCA1 and 2, VUS continue to pose an important clinical problem for geneticists when …

CRISPR Helps BRCA1 Researchers Determine Functional And Non-Functional Mutations Read More »