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Expert Review 07

Fetal RHD Screening in Clinical Routine

This paper explores an approach which uses non-invasive prenatal testing to determine the fetal RHD status, allowing targeted administration of antenatal anti-D prophylaxis only to those who will benefit from it. Learn more about the current strategies of fetal RHD and the experiences and considerations surrounding planning a fetal RHD screening program.

What you'll learn

  • Current strategies of fetal RHD screening
  • Requirements in clinical routine testing
  • Planning a fetal RHD screening program

Whitepaper preview

Fetal RHD determination by NIPT has mainly been conducted in research laboratories, but is now being introduced in routine laboratories, resulting in other demands. The procedures should be robust and standardized, and external quality control programs are required to confirm the stability of the test results offered to large populations [20]. Of course, high sensitivity and specificity of the technical platform is required, but it is equally important to optimize the pre-examination and post-examination processes. The pre-examination processes include the handling, preparation and storage of samples and the postexamination processes include interpretation and reporting of results.