Devyser Chimerism for NGS

Chimerism monitoring is now easier, more sensitive and more precise

Devyser Chimerism for NGS

Chimerism monitoring is now easier, more sensitive and more precise

Devyser Chimerism for NGS provides labs with one simple protocol for fast and reliable Chimerism measurement and monitoring in transplanted patients. Relapse monitoring is now improved thanks to high sensitivity and accurate measurement supported by a custom software that makes it easy to understand chimerism trends in patients.

“Early treatment made possible by more sensitive
diagnostic methods is expected to improve patient
survival and significantly reduce the costs for
management of transplant patients. ”

Dr. Dan Hauzenberger, M.D., Ph.D. Karolinska University Hospital, Stockholm, Sweden

” Early treatment made possible by more sensitive diagnostic methods is expected to improve patient survival and significantly reduce the costs for management of transplant patients.”

Dr. Dan Hauzenberger, M.D., Ph.D. Karolinska University Hospital, Stockholm, Sweden

Discover the advantages

High sensitivity for early detection

Very early detection of relapse is possible thanks to sensitivity and accurate measurement down to 0.1% minority fraction chimerism.

Easy to use

One tube NGS library prep with just 45 minutes hands-on time combined with powerful and intuitive data analysis and reporting software.

Fast and easy workflow from patient sample to report

A complete solution including NGS library preparation and analytical software for a unified workflow from initial screening of recipient/donor pairs to subsequent life-long patient monitoring.

Discover the advantages

High sensitivity for early detection

Very early detection of relapse is possible thanks to sensitivity and accurate measurement down to at least 0.1% fraction chimerism.

Easy to use

One tube NGS library prep with just 45 minutes hands-on time combined with powerful and intuitive data analysis and reporting software.

Fast and easy workflow from patient sample to report

A complete solution including NGS library preparation and analytical software for a unified workflow from initial screening of recipient/donor pairs to subsequent life-long patient monitoring.

See how it’s done

Play Video

Comparison of methods – Sensitivity and accuracy of Devyser Chimerism across the dynamic range

Chimerism analysis using NGS enables high sensitivity and accurate measurement throughout the dynamic range. This is achieved by combining the sensitive analysis of real-time PCR with the accurate measurements at high chimerism levels of STR fragment analysis.

Key features and benefits of Devyser Chimerism for NGS

High sensitivity allows very early detection of relapse

  • Detects down to 0.1% fraction of chimerism
  • Accurate and precise measurement over the entire dynamic range from 0.2 – 100% chimerism using a single method
  • Allows earlier detection of graft rejection and
    disease relapse.
  • One measurement method regardless of the level of mixed chimerism

     

Fast and effective workflow from patient sample to report

  • A single workflow for both screening and monitoring
  • Single-tube NGS method
  • Eliminates the need for sample-specific primers and patient-specific marker tracking
  • One universal reagent mix for all patients helps reduce reagent wastage and the need for keeping multiple reagents in stock

     

Easy to use

  • User-friendly, designed-for-purpose software with automatic marker identification and chimerism calculation
  • Screening samples are sequenced only once
  • Speeds up results analysis and eliminates manual data input
  • Saves time and increases lab productivity

NGS workflow

Devyser Chimerism NGS Library kit

NGS libraries are generated with one tube per sample.

Next Generation Sequencing (NGS)

Libraries are combined for simultaneous sequencing.

Data Analysis using ADVYSER for Chimerism

Analyse, follow-up and trend results in one easy-to-use software

 

Expert review 08

Overcoming limitations in the detection of mixed chimerism by Dr Dan Hauzenberger​

This paper highlights the importance of chimerism as a diagnostic tool for clinicians treating transplanted patients. Furthermore, the evolution of novel diagnostic tools for early detection of mixed chimerism is discussed. The recent development of NGS technology offers the possibility to analyse mixed chimerism with both sensitivity, as well as accurate and precise determination.

Learn more about how our single-tube NGS assay can help your team get the results they need.

Related products

Devyser Thalassemia

Complete NGS analysis of HBA1, HBA2 and HBB in a single run

Devyser FH

Single-tube NGS analysis of multiple genes involved in familial hypercholesterolemia (FH/ADH)

Devyser CFTR NGS

Enables fast and complete CFTR gene sequencing including CNV analysis in a single tube, CE-IVD NGS library prep kit

Devyser BRCA

Fast and complete characterisation of BRCA1 and BRCA2 with Devyser’s CE-IVD single tube, NGS library prep kit
  • Whitepapers
  • Downloads
  • Product details

IFU and software settings

Enter access code found in the lower right corner of the label on the kit box.

Certificates

Download a specific Batch Release Certificate (BRC) below by entering the BATCH/LOT number and then click on "Find".

Whitepapers

Overcoming limitations in the detection of mixed chimerism

The recent development of NGS technology offers the possibility to analyse mixed chimerism with both sensitivity, as well as accurate and precise determination. This paper highlights the importance of chimerism as a diagnostic tool for clinicians treating transplanted patients.

REQUEST PAPER

 

Product details

Research Use Only Kits

Name
Scope
Pack Size
Article Number
Devyser Chimerism
Screening and monitoring of mixed chimerism
24
8-A107-24-RUO
48
8-A107-48-RUO