Devyser Chimerism for NGS
Chimerism monitoring is now easier,
more sensitive and more precise
Devyser Chimerism for NGS provides labs with one simple protocol for fast and reliable Chimerism measurement and monitoring in transplanted patients. Relapse monitoring is now improved thanks to high sensitivity and accurate measurement supported by a custom software that makes it easy to understand chimerism trends in patients.
“Early treatment made possible by more sensitive
diagnostic methods is expected to improve patient
survival and significantly reduce the costs for
management of transplant patients. ”
Dr. Dan Hauzenberger, M.D., Ph.D. Karolinska University Hospital, Stockholm, Sweden
” Early treatment made possible by more sensitive diagnostic methods is expected to improve patient survival and significantly reduce the costs for management of transplant patients.”
Dr. Dan Hauzenberger, M.D., Ph.D. Karolinska University Hospital, Stockholm, Sweden
Discover the advantages
High sensitivity for early detection
Very early detection of relapse is possible thanks to sensitivity and accurate measurement down to 0.1% minority fraction chimerism.
Easy to use
One tube NGS library prep with just 45 minutes hands-on time combined with powerful and intuitive data analysis and reporting software.
Fast and easy workflow from patient sample to report
A complete solution including NGS library preparation and analytical software for a unified workflow from initial screening of recipient/donor pairs to subsequent life-long patient monitoring.
Discover the advantages
High sensitivity for early detection
Very early detection of relapse is possible thanks to sensitivity and accurate measurement down to at least 0.1% fraction chimerism.
Easy to use
One tube NGS library prep with just 45 minutes hands-on time combined with powerful and intuitive data analysis and reporting software.
Fast and easy workflow from patient sample to report
A complete solution including NGS library preparation and analytical software for a unified workflow from initial screening of recipient/donor pairs to subsequent life-long patient monitoring.
Case Study
A beneficial new method for chimerism monitoring
Dr. Dan Hauzenberger, Medical Director, Section of Transplantation Immunology at Sweden’s Karolinska University Hospital, on how new, highly sensitive and precise methods for mixed chimerism analytics are transforming post-transplant monitoring, enabling earlier detection and treatment to improve and save the lives of transplanted patients.
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Case Study
A beneficial new method for chimerism monitoring
Dr. Dan Hauzenberger, Medical Director, Section of Transplantation Immunology at Sweden’s Karolinska University Hospital, on how new, highly sensitive and precise methods for mixed chimerism analytics are transforming post-transplant monitoring, enabling earlier detection and treatment to improve and save the lives of transplanted patients.
See how it’s done
Comparison of methods – Sensitivity and accuracy of Devyser Chimerism across the dynamic range
Chimerism analysis using NGS enables high sensitivity and accurate measurement throughout the dynamic range. This is achieved by combining the sensitive analysis of real-time PCR with the accurate measurements at high chimerism levels of STR fragment analysis.
Key features and benefits of Devyser Chimerism for NGS
High sensitivity allows very early detection of relapse
- Detects down to 0.1% fraction of chimerism
- Accurate and precise measurement over the entire dynamic range from 0.2 – 100% chimerism using a single method
- Allows earlier detection of graft rejection and
disease relapse. - One measurement method regardless of the level of mixed chimerism
Fast and effective workflow from patient sample to report
- A single workflow for both screening and monitoring
- Single-tube NGS method
- Eliminates the need for sample-specific primers and patient-specific marker tracking
- One universal reagent mix for all patients helps reduce reagent wastage and the need for keeping multiple reagents in stock
Easy to use
- User-friendly, designed-for-purpose software with automatic marker identification and chimerism calculation
- Screening samples are sequenced only once
- Speeds up results analysis and eliminates manual data input
- Saves time and increases lab productivity
NGS workflow
Devyser Chimerism NGS Library kit
NGS libraries are generated with one tube per sample.
Next Generation Sequencing (NGS)
Libraries are combined for simultaneous sequencing.
Data Analysis using ADVYSER for Chimerism
Analyse, follow-up and trend results in one easy-to-use software
Expert review 08
Overcoming limitations in the detection of mixed chimerism by Dr Dan Hauzenberger
This paper highlights the importance of chimerism as a diagnostic tool for clinicians treating transplanted patients. Furthermore, the evolution of novel diagnostic tools for early detection of mixed chimerism is discussed. The recent development of NGS technology offers the possibility to analyse mixed chimerism with both sensitivity, as well as accurate and precise determination.
Learn more about how our single-tube NGS assay can help your team get the results they need.
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