Devyser HBOC for NGS

Pinpoint gene mutations with a recognised connection to the development of breast and ovarian cancers.

  • Detect mutations in genes with a recognised connection to the development of breast and ovarian cancers
  • Can be used as a follow-up after negative BRCA testing, or combined with Devyser BRCA for analysis of 14 genes in total
  • End-to-end CE-IVD solution including NGS library preparation and a customised data interpretation software
  • Targeted sequencing with high uniformity reduces sequencing costs by maximising sample capacity on every NGS flowcell
  • User friendly workflow with 45 mins hands-on time and a total laboratory process time of five hours from DNA to sequencing

Genes included in the Devyser HBOC CE-IVD gene panel

ATMPTENBARD1
RAD51CRAD51DBRIP1
CDH1STK11CHEK2
TP53NBNPALB2
BRCA1*BRCA2**Through combined protocol with Devyser BRCA
ATMPTEN
BARD1RAD51C
BRIP1RAD51D
CDH1STK11
CHEK2TP53
NBNPALB2
BRCA1*BRCA2*
*Through combined protocol with Devyser BRCA

Designed for genetic testing in hereditary breast and ovarian cancers

The Devyser HBOC gene panel has been developed with an integrative approach towards the varying literature and expert recommendations for follow-up after negative BRCA testing. It can also be employed as a first-line protocol simultaneously with BRCA1 and BRCA2, extending the screening by an additional 12 genes. Its purpose is to pinpoint mutations in genes with a recognised connection to the development of breast and ovarian cancers.

Quick and easy implementation

With ready-to-use reagents, less than 45 minutes hands-on time and customised data interpretation software, it is a good match for laboratories of any size. The targeted sequencing approach combined with uniform coverage of target regions maximises the output of relevant sequencing data in every run.

Identify variants to guide testing of at-risk relatives

Genetic testing of these genes may help guide treatment and management decisions. Identification of a disease-causing variant would also guide testing of at-risk relatives. This test is specifically designed for heritable germline mutations.

CE-IVD

Certified for In Vitro Diagnostics​

>98%

Assay uniformity

<45 min

Hands-on time

>92%

On-target reads

>99.9%

Clinical sensitivity and specificity

Watch video to see how it works

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Ready to test it out? Order a demo kit here.

Learn more about how our single-tube NGS assay can help your team get the results they need.

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IFU and software settings

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Certificates

Download a specific Batch Release Certificate (BRC) below by entering the BATCH/LOT number and then click on "Find".

Product details

CE-IVD Certified Kits

Name
Scope
Pack Size
Article Number
Devyser HBOC for NGS
Sequence variants in 12 genes known to significantly increase the risk of developing breast and ovarian cancer in germline samples. They are ATM, BARD1, BRIP1, CDH1, CHEK2, NBN, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53
24
8-A111-24
48
8-A111-48

Research Use Only Kits

Name
Scope
Pack Size
Article Number
Devyser HBOC for NGS
Sequence variants in 12 genes known to significantly increase the risk of developing breast and ovarian cancer in germline samples. They are ATM, BARD1, BRIP1, CDH1, CHEK2, NBN, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53
24
8-A111-24-RUO
48
8-A111-48-RUO