Single tube Thalassemia kit
Complete NGS analysis of HBA1, HBA2 and HBB in a single run with Devyser Thalassemia
Simple, fast and accurate
Using the Devyser Thalassemia kit, we can reduce both response time and costs.
One single assay provides all the information we need.
Prof. Dr Veysel Sabri Hancer,
Istinye University Genetic Diseases Diagnostic Centre, Istanbul, Turkey
Discover the advantages
Complete one-tube analysis
Single-tube NGS method for both SNV and CNV detection in HBA1, HBA2 and HBB
Fast and simple NGS workflow
From DNA to sequencing in less than 5 hours with less than 45 mins hands-on time
User-friendly data analysis software
Bypass complex and laborious data analysis with our tailored analytical software solution
One assay for all Thalassemia testing needs
Simple procedure to detect all mutations in HBA1, HBA2 & HBB
With the Devyser Thalassemia kit you can detect all mutations in HBA1, HBA2 and HBB using a single, one-tube NGS assay.
The assay detects single nucleotide polymorphisms (SNVs) Indels and CNVs. The extremely simple procedure makes it an excellent choice for any lab, whether you are running advanced second level genetic testing or large scale mutation screening.
The fast, simple and robust NGS workflow replaces complex multi-step protocols and eliminates the need for maintaining multiple Thalassemia assays in your lab.
Comprehensive CNV detection
Devyser’s proprietary PCR chemistry provides complete and uniform coverage of the relevant genetic regions by enabling a high level of overlapping amplicon multiplexing.
This simple workflow significantly reduces the risk for contamination and sample mix-up. Reliable detection of large structural deletion is further improved through the use of PCR primers aligned to both ends of 18 large deletions with high prevalence. Simultaneously, coverage based CNV analysis is used to confirm detected deletions and to identify additional large structural deletions in the targeted regions.
Devyser Thalassemia detects additional variants
In 15% of samples, additional pathogenic sequence variants were found with the majority in the other globin gene. These sequence variants had previously not been identified given that current analysis workflows often stop as soon as a pathogenic sequence variants is found in one of the two gene clusters.
125 characterised clinical samples analysed with Devyser Thalassemia NGS
100% of previously characterised pathogenic variants were detected.
15% of samples contained additional, previously undetected pathogenic variants.
See how it’s done
Simple NGS workflow
Only one tube per sample
Single tube library protocol dramatically reduces the risk for sample mix up or contamination and minimises the hands-on time
Pre-dispensed dual indices in strip/plate
All indexes are delivered pre–dispensed in strip or plate format to reduce the risk for sample mix up
or contamination and to minimise
the hands-on time
Sample pooling before cleanup and NGS
All patient samples are pooled to a single tube before clean-up, again reducing the hands-on time and simplifying the workflow
Data analysis
Bypass complex and laborious data analysis with our tailored analytical software solution
Simple graphical intepretation of sequence variants and CNV's
Complete NGS thalassemia data interpretation
Learn more about how our single-tube NGS assay can help your team get the results they need.
View poster on how it works
- Downloads
- Product details
IFU and software settings
Enter access code found in the lower right corner of the label on the kit box.
Certificates
Download a specific Batch Release Certificate (BRC) below by entering the BATCH/LOT number and then click on "Find".
Devyser Thalassemia Flyer
A simple NGS method for detection of sequence variants causing Alpha and Beta Thalassemia
Filesize: 513 KBProduct Information Booklet - One assay for all Thalassemia testing needs
Filesize: 4 MBSDS - Devyser Thalassemia
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We are specialists when it comes to diagnostic kits for complex DNA testing within oncology, reproductive health and hereditary diseases. Our products are used to guide targeted cancer therapies, to enable rapid prenatal diagnostics, as well as in a wide array of genetic tests. Routine diagnostic laboratories in more than 50 countries worldwide use our products.