Devyser FH NGS

Reduce hands-on time from days to minutes with Devyser’s easy-to-use NGS library prep kit for complete characterisation of genes involved in familial hypercholesterolemia.

Discover the advantages

  • Analyse all genes relevant for diagnosis of Familial Hypercholesterolemia (FH)
  • Simplify your laboratory workflow and reduce hands-on time to under 45 minutes
  • Detect CNVs in the LDLR gene

Detect all FH mutations

Familial Hypercholesterolemia, also known as Autosomal Dominant Hypercholesterolemia (ADH), can be caused by mutations in the LDLR, APOB, PCSK9, APOE, STAP1 and LDLRAP1 genes, all of which can be detected with Devyser’s FH kit. Raised LDL-cholesterol concentrations can also have a polygenic cause that might explain the variable penetrance of the disease. Devyser’s FH kit enables the analysis of 12 polygenic SNPs influencing the LDL-cholesterol level.

Genes included in the Devyser FH gene panel

LDLRAPOBPCSK9
LDLRAP1APOESTAP1

Genes included in the Devyser FH gene panel

LDLRAPOBPCSK9
LDLRAP1APOESTAP1

Sequencing of 12 polygenic FH SNPs

rs629301rs1564348rs1800562rs2479409
rs3757354rs4299376rs6511720rs8017377
rs11220462rs1367117 rs429358rs7412
Selection of relevant SNPs based on: Talmud et al, Lancet 2013; 381:1293-1301

Sequencing of 12 polygenic FH SNPs

rs629301rs1564348rs1800562rs2479409
rs3757354rs4299376rs6511720rs8017377
rs11220462rs1367117 rs429358rs7412
Selection of relevant SNPs based on: Talmud et al, Lancet 2013; 381:1293-1301

Predict the effects of statin therapy

Statin drugs are highly effective in lowering blood concentrations of LDL-cholesterol, with concomitant reduction in risk of major cardiovascular events. Although statins are generally regarded as safe and well-tolerated, there is an interindividual difference in the response to statin treatment and some users may develop muscle symptoms, myopathy. Devyser FH enables the detection of several SNPs associated with treatment effect and adverse reactions to statin therapy.

Sequencing of 6 SNPs involved in statin response

rs429358rs7412rs646776
rs4149056rs3798220rs10455872

Sequencing of 6 SNPs involved in statin response

rs429358rs7412rs646776
rs4149056rs3798220rs10455872

Benefits of FH mutation testing

The main benefit of a genetic diagnosis is that cascade testing can be used to identify affected biological relatives of FH index individuals and begin appropriate interventions early.

Designed for routine laboratory use

The Devyser FH kit is easy to implement and a highly cost-effective solution for NGS library preparation. With ready-to-use reagents and a user-friendly workflow, it suits both manual and automated processes.

Watch video to see how it works

Analytical software options

Laboratories have a choice of analytical software solutions, locally deployed or cloud-based.

Ready to test it out? Contact us here.

Ready to test it out? Order a demo kit here.

Learn more about how our single-tube NGS assay can help your team get the results they need.

Discover our range of NGS products

Devyser BRCA

Fast and complete characterisation of BRCA1 and BRCA2 with Devyser’s CE-IVD single tube, NGS library prep kit

Devyser HBOC

Complete sequencing of 12 genes with a recognised connection to the development of breast and ovarian cancers. CE-IVD

Devyser CFTR NGS

Enables fast and complete CFTR gene sequencing including CNV analysis in a single tube, CE-IVD NGS library prep kit

Devyser Chimerism

Devyser Chimerism for NGS provides labs with one simple protocol for fast and reliable Chimerism measurement and monitoring in transplanted patients

Are you an existing customer?

Batch release certificates and relevant IFU and software settings can be found here.

Whitepaper

Familial Hypercholesterolemia: Genetic Diagnosis and Cascade Testing Using NGS

FH is a greatly underdiagnosed autosomal disorder, with most patients suffering a cardiovascular event prior to diagnosis.
This paper offers advice on genetic testing for FH, and outlines how NGS can be used to perform cascade screening of related individuals.
  • Whitepapers
  • Downloads
  • Product details

IFU and software settings

Enter access code found in the lower right corner of the label on the kit box.

Certificates

Download a specific Batch Release Certificate (BRC) below by entering the BATCH/LOT number and then click on "Find".

Whitepapers

Familial Hypercholesterolemia: Genetic Diagnosis and Cascade Testing Using NGS

FH is a greatly underdiagnosed autosomal disorder, with most patients suffering a cardiovascular event prior to diagnosis. This paper offers advice on genetic testing for FH, and outlines how NGS can be used to perform cascade screening of related individuals.

Product details

Research Use Only Kits

Name
Scope
Pack Size
Article Number
Devyser FH v2
"Complete sequencing of the following genes: LDLR, APOB, PCSK9, APOE, STAP1, LDLRAP1 Sequence determination of the following polygenic SNPs related to FH and/or statin treatment response: rs629301, rs1564348, rs1800562, rs2479409, rs3757354, rs4299376, rs6511720, rs8017377, rs11220462, rs1367117, rs429358, rs7412, rs646776, rs4149056, rs3798220, rs10455872 "
24
8-A109-24-RUO
48
8-A109-48-RUO