Devyser FH for NGS

Devyser’s FH kit helps clinicians rapidly diagnose and perform cascade screening for monogenic and polygenic Familial Hypercholesterolemia (FH).

It identifies known and new variants in relevant genes with a single tube assay, while providing a quick prediction on the efficiency of specific statin response.

Devyser Familial Hypercholesterolemia for NGS

Rapidly identify and analyse all genes relevant to diagnose FH with a single assay

Clinicians can diagnose and cascade screenmonogenic and polygenicFH quickly, while getting a quick prediction on the efficiency of specific statin response.

Discover the benefits and advantages

Most comprehensive gene panel for FH on the market

With the Devyser FH kit, analyse all genes relevant for diagnosis of Familial Hypercholesterolemia - monogenic and polygenic causes of FH, as well as predict treatment efficacy in one easy-to-use test.

Identify 12 SNPs in polygenic FH & the 6 SNPs to predict statin response

Identify SNPs involved in diagnosing FH to predict the efficiency of specific statin responses and enable clinicians to provide the best standard of care quickly.

Get quick results with fast and simple workflow

One tube per patient simplifies laboratory workflows laboratory workflows with just 45 minutes hands-on time, decreases overall testing costs and reduces the risk of sample mix up and contamination.

  • Get a comprehensive genetic overview by analysing all genes relevant for FH diagnosis.

  • Prediction of stating response may help clinicians reduce potentially hazardous side effects and maximise effects of treatment.

    • Provides laboratories with a competitive edge, enabling them to offer clinicians the broadest genetic panel currently available for FH, including prediction of drug efficacy. 

    • One tube per patient analysed streamlines laboratory workflow, reduces analysis complexity and decreases turnaround time. Better results obtained faster with less work.

    • A significant reduction in the complexity of testing opens up for high-throughout screening as testing demands grow.

    • Get a comprehensive genetic overview by analysing all genes relevant for FH diagnosis

    • Prediction of stating response may help clinicians reduce potentially hazardous side effects and maximise effects of treatment.

      LDLR

      APOB

      PCSK9

      LDLRAP1

      APOE

      STAP1

      LDLR1APOB8PCSK9

      Sequencing of 12 polygenic FH SNPs

      LDLRAP1APOESTAP1
      rs629301rs1564348rs1800562rs2479409
      rs3757354rs4299376rs6511720rs8017377
      rs11220462rs1367117 rs429358rs7412
      Selection of relevant SNPs based on: Talmud et al, Lancet 2013; 381:1293-1301

      Expert review 06

      Familial Hypercholesterolemia: Genetic Diagnosis and Cascade Testing Using NGS

      This paper offers advice on genetic testing for FH, and outlines how NGS can be used to perform cascade screening of related individuals.

      Learn more about how our FH kit can help your team get the results they need.

      Do you have any questions about Devyser FH?

      Related products

      Devyser BRCA NGS

      Fast and complete characterisation of BRCA1 and BRCA2 with Devyser’s CE-IVD single tube, NGS library prep kit

      Devyser HBOC

      Complete sequencing of 12 genes with a recognised connection to the development of breast and ovarian cancers. CE-IVD

      Devyser CFTR NGS

      Enables fast and complete CFTR gene sequencing including CNV analysis in a single tube, CE-IVD NGS library prep kit

      Devyser Chimerism

      Devyser Chimerism for NGS provides labs with one simple protocol for fast and reliable Chimerism measurement and monitoring in transplanted patients
      • Downloads
      • Product details

      IFU and software settings

      Enter access code found in the lower right corner of the label on the kit box.

      Certificates

      Download a specific Batch Release Certificate (BRC) below by entering the BATCH/LOT number and then click on "Find".

      Product details

      Research Use Only Kits

      Name
      Scope
      Pack Size
      Article Number
      Devyser FH v2
      "Complete sequencing of the following genes: LDLR, APOB, PCSK9, APOE, STAP1, LDLRAP1 Sequence determination of the following polygenic SNPs related to FH and/or statin treatment response: rs629301, rs1564348, rs1800562, rs2479409, rs3757354, rs4299376, rs6511720, rs8017377, rs11220462, rs1367117, rs429358, rs7412, rs646776, rs4149056, rs3798220, rs10455872 "
      24
      8-A109-24-RUO
      48
      8-A109-48-RUO