Detection and monitoring of dd-cfDNA in patients following kidney transplantation

One severe complication following solid organ transplantation is antibody- and/or cell-mediated rejections of the graft. Early detection of rejection may therefore be of paramount importance to improve graft survival following solid organ transplantation. The present study was conducted to determine the monitoring capability and clinical utility of the Devyser assay designed for the sensitive detection of dd-cfDNA (donor-derived cell-free DNA) in patients following kidney transplantation.