Discover the advantages
- Analyze all genes relevant for diagnosis of Familial Hypercholesterolemia (FH)
- Simplify your laboratory workflow and reduce hands-on time to under 45 minutes
- Detect CNVs in the LDLR gene
Detect all FH mutations
Familial Hypercholesterolemia can be caused by mutations in the LDLR, APOB, PCSK9, APOE, STAP1 and LDLRAP1 genes, all of which can be detected with Devyser’s FH kit. Raised LDL-cholesterol concentrations can also have a polygenic cause that might explain the variable penetrance of the disease. Devyser’s FH kit enables the analysis of nine additional polygenic SNPs influencing the LDL-cholesterol level.
Predict the effects of statin therapy
Statin drugs are highly effective in lowering blood concentrations of LDL-cholesterol, with concomitant reduction in risk of major cardiovascular events. Although statins are generally regarded as safe and well-tolerated, there is an interindividual difference in the response to statin treatment and some users may develop muscle symptoms, myopathy. Devyser FH enables the detection of several SNPs associated with treatment effect and adverse reactions to statin therapy.
Benefits of FH mutation testing
The main benefit of a genetic diagnosis is that cascade testing can be used to identify affected biological relatives of FH index individuals and begin appropriate interventions early.
Designed for routine laboratory use
The Devyser FH kit is easy to implement and a highly cost-effective solution for NGS library preparation. With ready-to-use reagents and a user-friendly workflow, it suites both manual and automated processes.
Analytical software options
Laboratories have a choice of analytical software solutions, locally deployed or cloud-based.